2024 / 2023 / 2022 / 2021 / 2020 / 2019 / 2018 / 2017 / 2016 / 2015 / 2014 / 2013 / 2012 / 2011 / 1993-2010
2024
Xie R., Mulcahy B., Darbandi A., Marwah S., Ali F., L Y. Parlakgul G., Hotamisligil G., Wang B, MacParland S, Zhen M, Bader GD. Transfer learning improves performance in volumetric electron microscopy organelle segmentation across tissues. Submitted.
Li Y, Gong L, Wu J, Hung WL, Zhen, M., Gao S. UBR1 deficiency-mediated aberrant glutamate signaling leads to Ivermectin Resistance. Accepted. eLife. Preprint at BioRvix (PDF); https://doi.org/10.1101/2024.10.01.616045
Mladjenovic S, Chandok I, Darbandi A, Stordy B, Nguyen L, Zhen M, Warren C. 3D electron microscopy for nanoparticle tumour analysis. In press. PNAS.
Pan P, Zoberman M, Premachandran S, Bhatnagar S, Pilaka-Akella PP, Sun W, Zhang P, Li C, Martin C, Hung W, Zuo R, Pe K, Qin Z, Wang S, Li A, Zhen M, Saltzman AL, Calarco JA, Liu X. Robotic microinjection enables large-scale transgenic studies of Caenorhabditis elegans Nature Communications. In press. Nature Communications.
Yue Z, Li Y, Yu B, Xu Y, Chen L, Chitturi J, Meng J, Hung WL, Tian Y, El Mouridi S, Zhang C, Boulin T, Zhen M, Gao S. A Leak K+ Channel TWK-40 Regulates Rhythmic Motor Program in C. elegans. PNAS Nexus 3(7):234. (PDF); https://doi.org/10.1101/2022.04.09.487752
Das A, Franco J, Mulcahy B, Wang L, Chapman D, Jaisinghani C, Pruitt B, Zhen M, Goodman M. Conserved basal lamina proteins, laminin and nidogen, are repurposed to organize mechanosensory complexes responsible for touch sensation. Accepted. Current Biology. (PDF); https://doi.org/10.1101/2022.02.11.479800
Meng J, Ahamed T, Yu B, Hung W, El Mouridi S, Leclercq-Blondel A, Gendrel M, Wang Z, Chen L, Wen Q, Boulin T, Gao S, Zhen M. A tonically active master neuron continuously modulates mutually exclusive motor states at two-time scales. Science Advances 10(15):eadk0002. (PDF); https://www.science.org/doi/10.1126/sciadv.adk0002
Bach M, Bergs A, Mulcahy B, Zhen M, Gottschalk A. Coordinated electrical and chemical signaling between two neurons orchestrates switching of motor states. Submitted. Preprint at BioRxiv (PDF); https://doi.org/10.1101/2023.01.04.522780
Wu S, Hung W, Roy C, Li Y, Wang Y, Mulcahy B, Bessereau JL, Calarco J, Zhen M. Two Muscle-Specific and Direct Transcriptional Targets of DAF-16/FOXO Activated by Reduced Insulin/IGF-1 Signaling. Under review. Preprint at BioRvix (PDF); https://doi.org/10.1101/2022.12.09.519372
2023
Li Y, Chitturi J, Yu B, Zhang Y, Wu J, Ti P, Hung W, Zhen M, Gao S. The glutamate-gating ubiquitin ligase UBR-1 affects the synaptic strength between the GABAergic and glutamatergic signaling. EMBO Rep. 24(11):e57014. (PDF).
Cuentas-Condori A, Chen S, Gallick K, Krout M, Tipps J, Flautt L, Mulcahy B, Zhen M, Richmond J, Miller DM. The Epithelial Na+ Channel UNC-8 triggers an endocytic mechanism that recycles presynaptic components from old to new boutons in remodeling neurons. Cell Reports 42(11):113327. (PDF); https://doi.org/10.1101/2022.11.29.518248
Pavarino EC, Yang E, Dhanyasi N, Wang M, Bidel F, Lu X, Yang F, Mukesh BR, Drescher B, Hochner B, Katz PS, Zhen M, Lichtman JW, Meriovitch Y. mEMbrain: an interactive deep learning MATLAB tool for connectomic segmentation on commodity desktops. Frontiers in Neural Circuits 17:952921(PDF); https://doi.org/10.3389/fncir.2023.952921
Lin A, Qin S, Casademunt H, Wu M, Hung W, Cain G, Tan N, Valenzuela R, Lesanpezeshki L, Pehlevan C, Venkatachalam V, Zhen M, Samuel ADT. Functional imaging and quantification of multi-neuronal olfactory responses in C. elegans. Science Advances 9,eade1249 (PDF); https://doi.org/10.1126/sciadv.ade1249
2022
Mulcahy B, Witvliet D, Mitchell JM, Schalek RL, Berger D, Wu Y, Holmyard D, Lu Y, Ahamed T, Samuel ADT, Chisholm AD, Lichtman JW, Zhen M. Post-embryonic maturation of the C. elegans motor circuit. Current Biology 32(21): 4645-4659 (PDF); https://doi.org/10.1016/j.cub.2022.09.065
Lu Y, Ahamed T, Mulcahy B, Witvliet D, Guan SA, Hung W, Meng J, Wen Q, Samuel ADT, Zhen M. Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce a symmetric gait. Current Biology 32: 4631–4644 (PDF); https://doi.org/10.1101/2022.09.21.461278
Xu J, Liu Z, Zhang J, Chen S, Wang W, Zhao X, Zhen M, Huang X. N-end Rule-Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage. Diabetes db220362: 1-53. (PDF)
Varga BV, Faiz M, Yang H, Pivonkova H, Gao S, Khelifi G, Linderoth E, Zhen M, Hussein SM, Nagy A. Signal requirement for cortical potential of transplantable human neuroepithelial stem cells. Nature Communications 13(2844) (PDF); http://doi.org/10.1101/2021.03.27.437311
2021
Witvliet D, Mulcahy B, Mitchell JM, Meirovitch Y, Berger DR, Wu Y, Liu Y, Koh WR, Parvathala R, Holmyard D, Schalek RL, Shavit N, Chisholm AD, Lichtman JW, Samuel ADT, and Zhen M. Connectomes across development reveal principles of brain maturation. Nature 596:257-261(PDF); https://doi.org/10.1038/s41586-021-03778-8
Dong XK, Kheiri K, Lu YN, Xu ZY, Zhen M, Liu XY. Towards a live soft microrobot: optogenetic locomotion control of Caenorhabditis elegans. Science Robotics 6(55): eabe3950 (PDF); http://doi.org/10.1126/scirobotics.abe3950
Susoy V, Hung W, Witvliet D, Whitener JE, Wu M, Graham BJ, Zhen M, Venkatachalam V, Samuel ADT. Natural sensory context drives diverse brain-wide activity during C. elegans mating. Cell 184(20): 5122-5137.e17 Article plus supplementals
Britz S, Markert SM, Witvliet D, Steyer AM, Tröger S, Mulcahy B, Kollmannsberger P, Schwab Y, Zhen M, Stigloher C. Structural analysis of the C. elegans dauer larval anterior sensilla by Focused Ion Beam-Scanning Electron Microscopy. Frontiers In Neuroanatomy. 15:732520 (PDF; supplemental); https://doi.org/10.3389/fnana.2021.732520
Ji N, Venkatachalam V, Rodgers H, Hung W, Kawano T, Clark C, Lim M, Alkema MJ, Zhen M, Samuel ADT. Corollary neuron underlies motor feedback to sustain forward motor state. eLife 2021;10:e68848 (PDF); https://elifesciences.org/articles/68848
Wang Z, Zhu L, Zhang H, Li G, Yi C, Li Y, Yang Y, Ding Y, Zhen M, Gao S, Hsiai TK, Fei P. Real-time volumetric reconstruction of biological dynamics with light-field microscopy and deep learning. Nature Methods 18: 551-556 (PDF); https://www.nature.com/articles/s41592-021-01058-x
Chen L, Liu Y, Su P, Hung W, Li H, Wang Y, Yue Z, Ge M, Wu Z, Zhang Y, Fei P, Chen L, Tao L, Mao H, Zhen M, Gao S. Escape Steering by Cholecystokinin Peptidergic Signaling. Cell Reports 38(6): 110330. (PDF). https://www.sciencedirect.com/science/article/pii/S2211124722000468
2020
Markert SM, Skoruppa M, Yu B, Mulcahy, B, Zhen, M, Gao S, Sendtner M, Stigloher C. Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission. Biology Open 9: bio055129 (PDF); doi.org/10.1242/bio.055129
Tien C, Yu B, Huang M, Stepien K, Sugita K, Xie X, Han L, Monnier P, Zhen M, Rizo J, Gao S, Sugita S. Open syntaxin overcomes synaptic transmission defects in diverse C. elegans exocytosis mutants. Nature Communications 11(5516) (PDF); doi.org/10.1101/2020.01.10.901835
Yuan W, Zhang X, Qi X, Hung W, Florman J, Huo J, Xu T, Xie Y, Alkema M, Zhen M, Wen Q. Flexible motor sequence generation during stereotyped escape responses. eLife 2020;9:e56942 (PDF); 10.7554/eLife.56942
Zhao F, Yang Y, Li Y, Jiang H, Xie X, Yu T, Wang X, Liu Q, Zhang H, Jia H, Liu S, Zhen M, Zhu D, Gao S, Fei P. Efficient and cost‐effective 3D cellular imaging by sub‐voxel‐resolving light‐sheet add‐on microscopy. J. Biophotonics: 13(6), e201960243 (PDF); doi.org/10.1002/jbio.201960243
Luyben TT, Rai J, Li H, Georgiou J, Avila A, Zhen M, Collingridge GL, Tominaga T, Okamoto K. Optogenetic manipulation of postsynaptic cAMP using a novel transgenic mouse line enables synaptic plasticity and enhanced depolarization in the hippocampal dentate gyrus. Frontiers in Neural Circuits 14:24 (PDF); doi.org/10.3389/fncir.2020.00024
2019
Cuentas-Condori A, Mulcahy B, He S, Palumbos S, Zhen M, Miller DM. C. elegans neurons have functional dendritic spines. eLife 2019;8pii:e47918 (PDF); doi.org/10.7554/eLife.47918
Bakooshli MA, Lippmann ES, Mulcahy B, Tung K, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton R, Gilbert PM. A 3D Model of Human Skeletal Muscle Innervated with Stem Cell-derived Motor Neurons Enables Epsilon-subunit Targeted Myasthenic Syndrome Studies. eLife 2019;8:e44530 (PDF); doi.org/10.7554/eLife.44530
Ao Y, Zeng K, Yu B, Miao Y, Hung W, Zhen M, Yang X, Zhang Y, Gao S. An Upconversion Nanoparticle Enables Near Infrared-Optogenetic Manipulation of the C. elegans Motor Circuit. ACS Nano 13(3): 3373-3386 (PDF); doi.org/10.1021/acsnano.8b09270
Huang YC, Pirri JK, Rayes D, Gao S, Mulcahy B, Grant J, Saheki Y, Francis MM, Zhen M, Alkema AJ. Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans. eLife 2019;8:e45905 (PDF); doi.org/10.7554/eLife.45905
2018
Wen Q, Gao S, Zhen M. Caenorhabditis elegans Excitatory Ventral Cord Motor Neurons Derive Rhythm for Body Undulation. Phil. Trans. R. Soc. B. 373(1758) (PDF); doi.org/10.1098/rstb.2017.0370
Chitturi J, Hung W, Abdel Rahman AM, Wu M, Lim MA, Calarco JA, Baran R, Huang X, Dennis J, Zhen M. The UBR-1 Ubiquitin Ligase Regulates Glutamate Metabolism to Generate Coordinated Motor Pattern in C. elegans. PLoS Genet 14(4): e1007303 (PDF); doi.org/10.1371/journal.pgen.1007303
Gao S, Guan S, Fouad AD, Meng J, Huang Y, Li Y, Alcaire S, Hung W, Kawano T, Lu Y, Qi YB, Jin Y, Alkema M, Fang-Yen C, Zhen M. Excitatory Motor Neurons are Local Oscillators for Reverse Locomotion. eLife 2018;7:e29915 (PDF); doi.org/10.7554/eLife.29915
Xu T, Huo J, Shao S, Po M, Kawano T, Lu Y, Wu M, Zhen M, Wen Q. Descending pathway facilitates undulatory wave propagation in Caenorhabditis elegans through gap junctions. PNAS 115(19): E4493-E4502 (PDF); doi.org/10.1073/pnas.1717022115
Mulcahy B, Witvliet D, Holmyard D, Mitchell J, Chisholm A, Samuel ADT, Zhen M. A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System. Frontiers in Neural Circuits 12(94) (PDF); doi.org/10.3389/fncir.2018.00094
Kaltdorf KV, Theiss M, Markert SM, Zhen M, Dandekar T, Stigloher C, Kollmannsberger P. Automated Classification of Synaptic Vesicles in Electron Tomographs of C. elegans using Machine Learning. PLoS One Computational Biology 13(10):e0205348 (PDF); doi.org/10.1371/journal.pone.0205348
2017
Meng J, Ma X, Tao H, Jin X, Witvliet D, Mitchell JK, Zhu M, Dong M, Zhen M, Jin Y, Qi YB. Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation. Developmental Cell 41(2):180-194 (PDF); doi.org/10.1016/j.devcel.2017.03.022
Opperman KJ, Mulcahy B, Giles AC, Risley MG, Bimbaum RL, Tulgren ED, Dawson-Scully K, Zhen M, Grill B. The HECT family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development. Cell Reports19(4): 822-835 (PDF); doi.org/10.1016/j.celrep.2017.04.003
Park S, Bin NR, Yu B, Wong R, Sitarska E, Sugita K, MA K, Xu J, Tien CW, Algouneh A, Turlova E, Wang S, Siriya P, Shahid W, Kalia L, Feng ZP, Monnier P, Sun HS, Zhen M, Gao S, Rizo J, Sugita S. UNC-18 and Tomosyn antagonistically control synaptic vesicle priming downstream of UNC-13 in C. elegans. J Neurosci 37(36): 8797-8815 (PDF); doi.org/10.1523/JNEUROSCI.0338-17.2017
2016
Ardeshiri R, Mulcahy B, Zhen M, Rezai P. A hybrid microfluidic device for on-demand orientation and multidirectional imaging of C. elegans organs and neurons. Biomicrofluidics 10(6): 064111 (PDF); doi.org/10.1063/1.4971157
Lim MA, Chitturi J, Laskova V, Meng J, Findeis D, Wiekenbert A, Mulcahy B, Luo L, Li Y, Lu Y, Hung W, Qu Y, Ho C, Holmyard D, Ji N, McWhirter R, Samuel ADT, Miller DM, Schnabel R, Calarco JA, Zhen M. Neuroendocrine modulation sustains the C. elegans forward motor state. eLife 2016;5:e19887 (PDF); doi.org/10.7554/eLife.19887
Venkatachalam V, Ji N, Wang X, Clark C, Mitchell JK, Klein M, Tabone CJ, Florman J, Ji H, Greenwood J, Chisholm AD, Srinivasan J, Alkema MJ, Zhen M, Samuel ADT. Pan-neuronal imaging in roaming Caenorhabditis elegans. PNAS 113(8): E1082-8 (PDF); doi.org/10.1073/pnas.1507109113
Markert SM, Britz S, Proppert S, Lang M, Witvliet D, Mulcahy B, Sauer M, Zhen M, Bessereau JL, Stigloher C. Filling the gap: adding super-resolution to array tomography for correlated ultrastructural and molecular identification of electrical synapses at the C. elegans connectome. Neurophotonics 3(4):041802 (PDF); doi.org/10.1117/1.NPh.3.4.041802
2015
Murakami T, Qamar S, Lin JQ, Schierle GS, Rees E, Miyashita A, Costa AR, Dodd RB, Chan FT, Michel CH, Kronenberg-Versteeg D, Li Y, Yang SP, Wakutani Y, Meadows W, Ferry RR, Dong L, Tartaglia GG, Favrin G, Lin WL, Dickson DW, Zhen M, Ron D, Schmitt-Ulms G, Fraser P, Shneider NA, Holt C, Vendruscolo M, Kaminski CF, St George-Hyslop P. ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function. Neuron 88(4): 678-690 (PDF); doi.org/10.1016/j.neuron.2015.10.030
Park S, Bin N, Rajah MM, Kim B, Chou T, Kang SA, Sugita K, Parsaud L, Smith M, Monnier PP, Ikura M, Zhen M, Sugita S. Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans. Molecular Biology of the Cell 27(4): 669-685 (PDF); doi.org/10.1091/mbc.E15-09-0638
Maro GS, Gao S, Olechwier AM, Hung W, Liu M, Özkan E, Zhen M and Shen K. MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin. Neuron 86(4):1420-1432 (PDF); doi.org/10.1016/j.neuron.2015.05.015
Zhen M, and Samuel ADT. C. elegans locomotion: small circuits, complex functions. Current Opinion in Neurobiology 33: 117-126 (PDF); doi.org/10.1016/j.conb.2015.03.009
Aoyagi K, Rossignol E, Hamdan FF, Mulcahy B, Xie L, Nagamatsu S, Rouleau GA, Zhen M, Michaud JL. A gain-of-function mutation in NALCN in a child with intellectual disability, ataxia, and congenital arthrogryposis. Human Mutation 36(8): 753-757 (PDF); doi.org/10.1002/humu.22797
Lant B, Yu B, Goudreault M, Holmyard D, Knight JD, Xu P, Zhao L, Chin K, Wallace E, Zhen M, Gingras AC, Derry WB. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Nature Communications 6: 6449 (PDF); doi.org/10.1038/ncomms7449
Wang J, Chitturi J, Ge Q, Laskova V, Wang W, Li X, Ding M, Zhen M, Huang X. The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development 142: 1447-57 (PDF); doi.org/10.1242/dev.119479
Gao S, Xie L, Kawano T, Po MD, Pirri JK, Guan S, Alkema MJ, Zhen M. The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion. Nature Communications 6: 6323 (PDF; supplemental); doi.org/10.1038/ncomms8191
2014
Norris AD, Gao S, Norris ML, Ray D, Ramani AK, Fraser AG, Morris Q, Hughes TR, Zhen M, Calarco JA. A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types. Molecular Cell 54(6): 946-59 (PDF); doi.org/10.1016/j.molcel.2014.05.004
Hung W, Wang Y, Chitturi J, Zhen M. A Caenorhabditis elegans developmental decision requires insulin signaling mediated neuron-intestine communication. Development 141(6): 1767-79 (PDF); doi.org/10.1242/dev.103846
2013
Hung W, Hwang C, Gao S, Liao E, Chitturi J, Wang Y, Li H, Stigloher C, Bessereau JL, Zhen M. Attenuation of insulin signaling contributes to FSN-1-mediated regulation of synapse development. EMBO J 32(12): 1745-1760 (PDF); doi.org/10.1038/emboj.2013.91
Qi Y, Po MD, Mac P, Kawano T, Jorgensen E, Zhen M, Jin Y. Hyperactivation of B-type motor neurons results in aberrant synchrony of the Caenorhabditis elegans motor circuit. Journal of Neuroscience 33(12): 5319-5325 (PDF); doi.org/10.1523/JNEUROSCI.4017-12.2013
Xie L, Gao S, Alcaire SM, Aoyagi K, Wang Y, Stagljar I, Nagamatsu S, Zhen M. NLF-1 delivers a sodium leak channel to regulate neuronal excitability and modulate rhythmic locomotion. Neuron 77(6): 1069-1082 (PDF); doi.org/10.1016/j.neuron.2013.01.018
2012
Wen Q, Po MD, Wyart M, Chklovskii DB, Zhen M, Samuel ADT. Proprioceptive coupling within motor neurons drives C. elegans forward locomotion. Neuron 76(4): 750-761 (PDF); doi.org/10.1016/j.neuron.2012.08.039
Najarro EH, Wong L, Zhen M, Carpio EP, Goncharov A, Garriga G, Jin Y, Ackley B. Caenorhabditis elegans Flamingo Cadherin fmi-1 Regulates GABAergic Neuronal Development. Journal of Neuroscience 32(14): 4196-4211 (PDF); doi.org/10.1523/JNEUROSCI.3094-11.2012
Po MD, Calarco JA, Zhen M. Releasing the inner inhibition for axon regeneration. Neuron 73(2): 207-209 (PDF); doi.org/10.1016/j.neuron.2012.01.002
Murakami T, Yang SP, Xie L, Kawano T, Fu D, Mukai A, Bohm C, Chen F, Robertson J, Suzuki H, Tartaglia GG, Vendruscolo M, Schierle GSK, Chan FT, Moloney A, Crowther D, Kaminski CF, Zhen M, St George-Hyslop P. ALS mutations in FUS causes neuronal dysfunction and death in by a dominant gain-of-function mechanism independent of TDP-43. Human Molecular Genetics 21(1): 1-9 (PDF); doi.org/10.1093/hmg/ddr417
2011
Kawano T, Po MD, Gao S, Leung G, Ryu WE, Zhen M. An imbalancing act: gap junctions reduce the backward motor circuit activity to bias C. elegans for forward locomotion. Neuron 17(4): 572-587 (PDF; supplemental); doi.org/10.1016/j.neuron.2011.09.005
Mok CA, Healey MP, Shekhar T, Leroux MR, Héon E, Zhen M. Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans. PLoS Genetics 7(10): e1002335 (PDF); doi.org/10.1371/journal.pgen.1002335
Gao S and Zhen M. Action potentials drive body wall muscle contractions in Caenorhabditis elegans. Proceedings in the National Academy of Science USA 108(6): 2557-2562 (PDF); doi.org/10.1073/pnas.1012346108
Stigloher C, Zhan H, Zhen M, Richmond J, Bessereau JL. The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions. Journal of Neuroscience 31(12): 4388-4396 (PDF); doi.org/10.1523/JNEUROSCI.6164-10.2011
Bouhours M, Po MD, Gao S, Hung W, Li H, Georgiou J, Roder JC, Zhen M. A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel. Molecular Brain 4(16) (PDF); doi.org/10.1186/1756-6606-4-16
Sancar F, Touroutine D, Gao S, Oh HJ, Gendrel M, Bessereau JL, Kim H, Zhen M, Richmond JE. The dystrophin-associated protein complex maintains muscle excitability by regulating Ca(2+)-dependent K(+) (BK) channel localization. Journal of Biological Chemistry 286(38): 33501-10 (PDF); doi.org/10.1074/jbc.M111.227678
Calarco JA, Zhen M, Blencowe BJ. Networking in a global world: establishing functional connections between neural splicing regulators and their target transcripts. RNA 17: 775-91 (PDF); doi.org/10.1261/rna.2603911
Ramani AK, Calarco JA, Pan Q, Mavandadi S, Wang Y, Nelson AC, Lee LJ, Morris Q, Blencowe BJ, Zhen M, Fraser AG. Genome-wide analysis of alternative splicing in Caenorhabditis elegans. Genome Research 21: 342-348 (PDF); doi.org/doi/10.1101/gr.114645.110
Souza RP, Rosa DV, Romano-Silva MA, Zhen M, Meltzer HY, Lieberman JA, Remington G, Kennedy JL, Wong AH. Lack of association of NALCN genetic variants with schizophrenia. Psychiatry Research 185: 450-452 (PDF); doi.org/10.1016/j.psychres.2010.07.009
1993-2010
Kim JS, Hung W, Narbonne P, Roy R, Zhen M. (2010). C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization. Development 137: 93-102 (PDF); doi.org/10.1242/dev.041459
Po M, Hwang C, Zhen M. (2010). PHRs: bridging axon guidance, outgrowth and synapse development. Current Opinion in Neurobiology 20: 100-107 (PDF); doi.org/10.1016/j.conb.2009.12.007
Kim JSM, Hung W, Zhen M. (2010). The long and the short of SAD-1 kinase. Communicative and Integrative Biology 3(3): 1-5 (PDF); doi.org/10.4161/cib.3.3.11455
Mok C, Heon E, Zhen M. (2010). Ciliary dysfunction and obesity. Clinical Genetics 77: 18-27 (PDF); doi.org/10.1111/j.1399-0004.2009.01305.x
Yeh E, Kawano T, Ng S, Fetter R, Hung W, Wang Y, Zhen M. (2009). Caenorhabditis elegans innexins regulate active zone differentiation. Journal of Neuroscience 29(16): 5207-17 (PDF); doi.org/10.1523/JNEUROSCI.0637-09.2009
Calarco JA, Superina S, O’Hanlon D, Gabut M, Raj B, Pan Q, Skalska U, Clarke L, Gelinas D, van der Kooy D, Zhen M, Ciruna B, Blencowe BJ. (2009). Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. Cell 138: 1-13 (PDF); doi.org/10.1016/j.cell.2009.06.012
Yeh E, Ng S, Zhang M, Bouhours M, Wang Y, Wang M, Hung W, Aoyagi K, Melnik-Martinez K, Li M, Liu F, Schafer WR, Zhen M. (2008). A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans. PLoS Biology 6(3): e55 (PDF); 10.1371/journal.pbio.0060055
Liewald JF1, Brauner M, Stephens GJ, Bouhours M, Schultheis C, Zhen M, Gottschalk A. (2008). Optogenetic analysis of synaptic function. Nature Methods 5(10): 895-902 (PDF); doi.org/10.1038/NMETH.1252
Kim JS, Lilley BN, Zhang C, Shokat KM, Sanes JR, Zhen M. (2008). A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation. Neural Development 3(23) (PDF); doi.org/10.1186/1749-8104-3-23
Li C, Inglis PN, Leitch CC, Efimenko E, Zaghloul NA, Mok CA, Davis EE, Bialas NJ, Healey MP, Héon E, Zhen M, Swoboda P, Katsanis N, Leroux MR. (2008). An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes. PLoS Genetics 4(3): e1000044 (PDF); doi.org/10.1371/journal.pgen.1000044
Gao MX, Liao EH, Yu B, Wang Y, Zhen M, Derry WB. (2008). The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans. Cell Death and Differentiation 15: 1054-1062 (PDF); doi.org/10.1038/cdd.2008.30
Wang W, Bouhours M, Gracheva EO, Liao EH, Xu K, Sengar AS, Xin X, Roder J, Boone C, Richmond JE, Zhen M, Egan SE. (2008). ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Traffic 9: 742–754 (PDF); doi.org/10.1111/j.1600-0854.2008.00712.x
Kim JS and Zhen M. (2008). Protons as intracellular messengers. Cell 132: 21-22 (PDF); doi.org/10.1016/j.cell.2007.12.020
Kim JS and Zhen M. (2008). Neuronal polarity. Encyclopedia of Neuroscience, Springer-Verlag. doi.org/10.1007/978-3-540-29678-2_3921
Hung W, Hwang C, Po MD, Zhen M. (2007). Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans. Development 134: 237-249 (PDF); doi.org/10.1242/dev.02725
Patel MR, Lehrman EK, Poon VY, Crump JG, Zhen M, Bargmann CI, Shen K. (2006). Hierarchical assembly of presynaptic components in defined C. elegans synapses. Nature Neuroscience 9(12): 1488-1498 (PDF); doi.org/10.1038/nn1806
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