News

  • Science Robotics Jul2021

    Coming soon (July 2021) in Science Robotics: Towards a live soft microrobot: optogenetic locomotion control of Caenorhabditis elegans

  • Rory Gao

    Welcome to Rory Gao, an Engineering Science student at the University of Toronto who is joining us for a summer student!

  • Ni Ji – elife

    Congratulations to Ni Ji et al. – Corollary neuron underlies motor feedback to sustain forward motor state now at eLife (PDF)

  • Witvliet in nature

    Witvliet et al. Connectomes across development reveal principles of brain maturation in C. elegans was recently accepted in Nature (preprint). Congratulations!

  • Real-time volumetric in Nature Methods

    Now available in Nature Methods – Wang et al. Real-time volumetric reconstruction of biological dynamics with light-field microscopy and deep learning (PDF)

  • Welcome Leila Lesanpezeshki

    Welcome to Leila Lesanpezeshki – a new postdoctoral fellow who joins us from Texas Tech.
    Leila’s PhD focused on developing phenotypic assays to study the neuromuscular function of C. elegans. She developed a 3D burrowing assay using a hydrogel to rapidly assess neuromuscular health in C. elegans disease models. In a NASA funded project, she collaborated on sending worms to space to understand the effect of microgravity on muscle strength during spaceflight using a microfluidic technology developed in her PhD lab. As an engineer at Zhen Lab, she will be leveraging her microfluidic knowledge to develop new assays to understand how neural connectivity affects the behavior and neuromuscular function.

  • We are pleased to welcome Jiacheng (Jackie) Chen!

    We are pleased to welcome Jiacheng (Jackie) Chen, a new PhD student, to the lab.

  • 2020 publications round up

    A round-up of publications for 2020, great output with our colleagues:
    Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission. Markert et al. Biology Open (PDF)
    Open syntaxin overcomes synaptic transmission defects in diverse C. elegans exocytosis mutants. Tien et al. Nature Communications (PDF)
    Flexible motor sequence generation during stereotyped escape responses. Yuan et al. eLife (PDF)
    Efficient and cost‐effective 3D cellular imaging by sub‐voxel‐resolving light‐sheet add‐on microscopy. Zhao et al. J. Biophotonics (PDF)
    – Optogenetic manipulation of postsynaptic cAMP using a novel transgenic mouse line enables synaptic plasticity and enhanced depolarization in the hippocampal dentate gyrus. Luyben et al. Frontiers in Neural Circuits (PDF)

  • Capturing the Continuous Complexity of Behavior in C. elegans

    Capturing the Continuous Complexity of Behavior in C. elegans. Congratulations to Tosif Ahamed and Greg J. Stephens on this outstanding work published in Nature Physics! (PDF)

  • Welcome to our four Fall20/Winter21 undergrads!

    Welcome to our four Fall20/Winter21 undergrads – Samuel Wu, Alice Xu, Mohammad Haddadnia, and Randa Higazy is a 4th year thesis student!

  • Welcoming Neeaja Ramakrishnan!

    Welcoming Neeaja Ramakrishnan to the PhD program in physiology after her recent reclassification exam. Congratulations!  

  • Good-bye to Maggie Chang

    Good-bye to Maggie Chang, who was with the lab from 2016-2020. We wish her well as she commences a PhD program in biology at McGill. 

  • Congratulations to Daniel Witvliet!

    Congratulations to Daniel Witvliet for his second place win for “Reconstructing the Minds of a Worm” in the 2020 Show Us Your Brain Contest. See the video at the NIH BRAIN Initiative website.
    For all the winners, click here

  • Well done on the hard work to Mona Wong!

    Well done on the hard work to Mona Wong! She has transferred from the MSc program to a PhD. 

  • Many congratulations to Daniel Witvliet!

    Many congratulations! Daniel Witvliet successfully defended his PhD in June. He’s now a PDF at Harvard.

  • Congratulations to Yangning Lu!

    Congratulations are in order! Yangning Lu successfully defended his PhD in February and has moved on to a postdoctoral fellowship at MIT. 

  • 2019 publications round up

    A round-up of publications for 2019, great output with our colleagues:
    C. elegans neurons have functional dendritic spines. Cuentas-Condori et al. eLife (PDF)
    – A 3D Model of Human Skeletal Muscle Innervated with Stem Cell-derived Motor Neurons Enables Epsilon-subunit Targeted Myasthenic Syndrome Studies. Bakooshli et al. eLife (PDF)
    – An Upconversion Nanoparticle Enables Near Infrared-Optogenetic Manipulation of the C. elegans Motor Circuit. Ao et al. ACS Nano (PDF)
    – Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans. Huang et al. (PDF)

  • Welcome to Hongruo Zhang, William Li, and Julian Moran!

    We are excited to welcome three new graduate students: Hongruo Zhang, William Li, and Julian Moran.

  • Welcome to Tosif!

    Welcome to Tosif Ahamed, our new Postdoctoral Fellow, from Okinawa! He is handling the cold shock alright.

  • Congratulations to Daniel and Lisa on becoming parents!

    Congratulations to Daniel and Lisa on becoming parents! Welcome, baby Andrew Zhao Witvliet! 

  • An upconversion nanoparticle enables near infrared-optogenetic stimulation

    With Shangbang Gao: An upconversion nanoparticle enables near infrared-optogenetic stimulation, ACS Nano (PDF)

  • Welcome to our new graduate student, Mona Wong!

    Welcome to our new graduate student, Mona Wong!

  • Congratulations to Min for completing his MSc study

    Congratulations to Min Wu for completing his MSc study!

  • An automated vesicle clustering algorithm

    With Christian Stigloher and Philip Kollmannsberger: An automated vesicle clustering algorithm, PLoS One (PDF)

  • Congratulations! Ben, Daniel, and our collaborators

    Congratulations! Ben, Daniel, and our collaborators. Our EM method paper on the C. elegans connectomics is online. The first paper from this long and hard journey is finally out (PDF)

  • A review on the C. elegans motor circuit

    With Quan Wen and Shangbang GaoA review on the C. elegans motor circuit, now published in Royal Philosophical Transactions B. (PDF)

  • Congratulations to our collaborator, the Wen lab

    Congratulations to our collaborator, the Wen lab. Their study of the forward motor circuit oscillator is accepted for publication by the PNAS. Glad to be part of this nice work

  • A rare genetic disorder JBS is likely a glutamate homeostasis metabolic disorder

    Congratulations to Jyothsna, Ria, Wesley, Renee, and our collaborators the Calarco and Dennis labs. Our finding that a rare genetic disorder JBS is likely a glutamate homeostasis metabolic disorder, via worm behaviors is accepted for publication at the PLoS Genetics

  • Excitatory motor neurons are the C. elegans oscillators

    Congratulations to Shangbang, Asuka, Jun, and our collaborators – the Jin, Alkema and Fang-Yen labs – for decoding oscillators of the C. elegans motor circuit 

  • Welcome, Katarina

    Katarina Pankova completed her PhD at the Ludwig Maximilian University of Munich. She will be joining our lab as a postdoctoral fellow

  • Welcome, Charline

    Charline Roy, a visiting PhD student from the Bessereau Lab joined us this fall. Welcome to Canada!

  • ZM10,000!

    As of today, the Zhen lab generated 10,000 worm strains! Congratulations to Wesley Hung, who made the ZM10,000

  • Funded by CIHR

    Our mission, studying the basic biology of the C. elegans neural circuit development and function, has been awarded a CIHR Foundation Grant in the 2016-2017 competition. We are grateful for this opportunity